Robert Rodriguez just announced that a Predators sequel is on the way. As far as him directing it he is still unsure about that. He might do Sin City 2 first so be on the lookout.
Check out what he said.
“[The studio] said, ‘Let’s do some other ones. What other story ideas do you have? Because it was like, let’s test out the market with this one. They really wanted it to be pretty contained, pretty scaled-back. They didn’t want to put too many of the ideas into it that we could save for a second one. So we could see what the appetite was, because the bigger movie would actually be what comes following that. That kind of sets up a new storyline, new location and world, and then you can really go crazy from there.”